During rehabilitation following an acute hospital stay, medications that block neurotransmitters may be overprescribed to older patients suffering from delirium superimposed on dementia, according to health researchers.
Specifically, strong anticholinergic medications may be prescribed to older adults when there are other suitable options. An anticholinergic medication blocks the neurotransmitter acetylcholine in the nervous system. These drugs are prescribed for a variety of symptoms, including incontinence, depression and insomnia. While their use can be very beneficial to some, they are also known to have significant adverse effects.
“In this study, people on anticholinergic medications had worse attention and physical function, and a longer stay (at the rehab facility) by four days, when compared to patients not on these medications,” said Ann Kolanowski, professor of nursing, Penn State.
The researchers observed 99 patients for 30 days, or until they were released, beginning the day they entered rehabilitation. Upon entering the rehab facility, all of the participants had both delirium and dementia, were 65 or older and did not have any other neurological problems.
The participants’ cognition and physical function were assessed daily by research staff. Physical function was measured by noting the amount of time and assistance patients needed to complete a task, such as feeding and dressing themselves and walking. Among other measures, patients’ cognition was measured by being given increasingly longer sequences of numbers to repeat both forwards and backwards until they missed two sequences in a row. Kolanowski and colleagues report their findings in a recent issue of the American Journal of Geriatric Psychiatry.
Anticholinergic drugs are ranked in the study according to their effect on cognition as mild, moderate and severe. A quarter of the patients were taking a medication with a moderate or severe anticholinergic effect, while 15 percent of the patients were not taking any anticholinergic medications. The remaining patients were taking a medication with mild anticholinergic effects.
The researchers found that patients who had been taking a medication with moderate or severe anticholinergic effects performed more poorly on a test of attention than they had during the previous week and also had lower physical function than the previous week.
“For people with dementia, the loss of physical function is a major risk factor for permanent institutionalization, and contributes heavily to the national burden of healthcare costs,” said the researchers. “The goal of post-acute care is to optimize function. For people with dementia, appropriate anticholinergic medication management may help achieve rehabilitation goals and reduce the cost of care.”
Jacqueline Mogle, assistant professor, Donna M. Fick, Distinguished Professor and director, Hartford Center of Geriatric Nursing Excellence, Nikki Hill, assistant professor, Paula Mulhall, research technologist, Liza Behrens, doctoral student, and Elise Colanecco, doctoral student, all College of Nursing, Penn State; Noll Campbell, research assistant professor, pharmacy, Purdue University; Malaz Boustani, professor, medicine, Indiana University; and Linda Clare, professor, clinical psychology, Washington Singer Laboratories, University of Exeter; all collaborated on this research as well.
The National Institute of Nursing Research at the National Institutes of Health supported this research.
Victoria M. Indivero